Rheumatoid factor, cryoglobulins, direct antiglobulin test and cold agglutinin titre results can be positive.
2.
A direct antiglobulin test ( Coombs test ) is also performed as part of the antibody investigation.
3.
To determine the autoantibody or autoantibodies present in a patient, the Coombs test, also known as the antiglobulin test, is performed.
4.
There are two types of Coombs tests, direct and indirect; more commonly, the direct antiglobulin test ( DAT ) is used.
5.
It can also be ordered along with a direct antiglobulin test when a patient is suspected of having a transfusion reaction or symptoms of autoimmune hemolytic anemia.
6.
In 1946, Boorman, Dodd, and Loutit applied the direct antiglobulin test to a variety of hemolytic anemias, and laid the foundation for the clear distinction of autoimmune from congenital hemolytic anemia.
7.
Laboratory assessment is based on a positive Direct Antiglobulin Test ( DAT ), a decrease in serum haptoglobin, and an increase in blood levels of the enzyme lactate dehydrogenase and indirect bilirubin levels.
8.
Of these developments, the antiglobulin test described by Coombs, Mourant, and Race in 1945 has proved to be one of the more important, useful tools now available for the detection of immune hemolytic states.
9.
In rare cases this can cause a baby to have a weakly positive DAT ( direct antiglobulin test ) due to sensitization of fetal cells from mothers who have received multiple doses of Rho ( D ) immune globulin.
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